Located along I-44 in the beautiful Ozark Highlands in the town of St. James, MO. St. James Winery is a fun place to visit fo ... r a day trip or that exercise stop on the long drive between here & there. Founded in 1970 by Pat & Jim Hofherr, St. James Winery has grown to become one of the largest producing wineries in Missouri. There are more than 160 estate acres of vineyard growing in excess of a dozen varieties of grapes that become some of the best and most awarded wines in the nation. Located on the North outer road of I-44 our official address is: 540 State Route B St. James, MO 65559-8110 800 280-9463 read more