ONO PHARMA USA, INC. (OPUS) was established in 1998 as the US subsidiary of Ono Pharmaceutical Co., Ltd. (ONO), an R&D-orient ... ed pharmaceutical company founded in 1717 with headquarters in Osaka, Japan. For more than 300 years ONO has made progress in our commitment to relieve patients' pain, focus on their health improvement and succeed in delivering "First in class" medicines, such as OPDIVO® (nivolumab), to patients. OPUS is pursuing overseas clinical trials of our new drug candidates and continuously and vigorously promotes licensing activities as a potential means of expanding our development pipeline and globally marketing new drugs that we develop. read more