It is not a question of if molecular profiling—the gamut of omics technologies—will enter the clinic, or even when. Clinical ... omics is happening now. And so, questions about clinical omics are taking a more practical turn, particularly for those who have a professional interest in overseeing, or at least accommodating, omics’ transformation of medicine. Professionals in the clinic and the laboratory need an information resource that will help them anticipate innovations in treatment and prevention. Mainstream resources are too general, and much of the research literature is too focused on the pioneering of new knowledge, not the consolidation of existing knowledge, that is, the development and standardization of best practices. A new resource, one that focuses on the most clinically relevant information, is overdue. Already, clinicians are systematically evaluating the benefits of sequencing technologies, building data repositories, and tackling practicalities such as reimbursement and protocols for incidental findings. Moreover, even as single-gene effects are informing clinical decisions, system-level processes are being scrutinized for ways to distinguish between wellness and ill health. Multidimensional, computationally rich approaches represent the next wave of innovation, taking personalized medicine to the next level, while demanding more of practitioners, who in turn demand convenient, informative updates on the ever-changing state of clinical omics. As such, the time is ripe for this publication, Clinical OMICS. read more